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Título: | Antibiotic resistance free plasmid DNA expressing LACK protein leads towards a protective Th1 response against Leishmania infantum infection |
Autor: | Ramos, Irene CSIC ORCID; Alonso, Ana CSIC ORCID ; Peris, Ana; Marcen, Jose Miguel; Abengozar, M. A. CSIC; Alcolea, Pedro J. CSIC ORCID ; Castillo Hernández, Juan Antonio; Larraga, Vicente CSIC ORCID | Palabras clave: | Leishmania infantum Canine visceral leishmaniasis LACK Antibiotic resistance free DNA vaccine Modified vaccinia virus Ankara |
Fecha de publicación: | 12-nov-2009 | Editor: | Elsevier | Citación: | Vaccine 27(48):6695-6703(2009) | Resumen: | Canine visceral leishmaniasis is a serious public health concern in the Mediterranean basin since dogs are the main Leishmania infantum reservoir. However, there is not a vaccination method in veterinary use in this area, and therefore the development of a vaccine against this parasite is essential for the possible control of the disease. Previous reports have shown the efficacy of heterologous prime-boost vaccination with the pCIneo plasmid and the poxvirus VV (both Western Reserve and MVA strains) expressing L. infantum LACK antigen against canine leishmaniasis. As pCIneo-LACK plasmid contains antibiotic resistance genes, its use as a profilactic method is not recommended. Hence, the antibiotic resistance gene free pORT-LACK plasmid is a more suitable tool for its use as a vaccine. Here we report the protective and immunostimulatory effect of the prime-boost pORT-LACK/MVA-LACK vaccination tested in a canine experimental model. Vaccination induced a reduction in clinical signs and in parasite burden in the liver, an induction of the Leishmania-specific T cell activation, as well as an increase of the expression of Th1 type cytokines in PBMC and target organs | Descripción: | 9 páginas, 6 figuras, 2 tablas -- PAGS nros. 6695-6703 | Versión del editor: | http://dx.doi.org/10.1016/j.vaccine.2009.08.091 | URI: | http://hdl.handle.net/10261/53216 | DOI: | 10.1016/j.vaccine.2009.08.091 | ISSN: | 0264-410X |
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