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dc.contributor.authorPichel, José G.-
dc.contributor.authorFernández-Moreno, Carmen-
dc.contributor.authorVicario-Abejón, Carlos-
dc.contributor.authorTestillano, P.S.-
dc.contributor.authorPatterson, Paul H.-
dc.contributor.authorPablo, Flora de-
dc.date.accessioned2012-07-11T11:25:48Z-
dc.date.available2012-07-11T11:25:48Z-
dc.date.issued2003-03-
dc.identifier.citationMechanisms of Development 120(3):349-361(2003)es_ES
dc.identifier.issn0925-4773-
dc.identifier.urihttp://hdl.handle.net/10261/53155-
dc.description13 páginas, 10 figuras, 1 tabla -- PAGS nros. 349-361es_ES
dc.description.abstractThe multifunctional proteins leukemia inhibitory factor (LIF) and insulin-like growth factor I (IGF-I) are expressed in overlapping patterns during development and, therefore, may act cooperatively. We show that mice doubly deficient in LIF and IGF-I all died at birth of apparent respiratory failure. Growth retardation, muscle hypoplasia and delayed ossification in IGF-I-deficient E18.5 mice were exacerbated by the absence of LIF. The transcription factor Sp3 was decreased in the skeleton of the double null mice. Pronounced depletion of olfactory bulb neurons, in contrast, was only IGF-I-dependent. The lungs displayed reduced air space in the IGF-I-deficient embryos and neonates, phenotype exacerbated in the double nulls, which showed abnormal epithelial cells and decreased Sp3 expression. In addition, the transcription factor TTF-1 and the surfactant protein B were lower in the lung of the double null neonates than in all other genotypes. LIF and IGF-I, thus, have cooperative and distinct tissue functions during development. Their essential role in bone ossification apparently involves Sp3, and in lung maturation Sp3 together with TTF-1es_ES
dc.description.sponsorshipThis study was funded by grants PM 97-0143 and BMC 2001-2132 from the MEC and MCYT (Spain) to F. de P. J.G.P. and C.V.-A. are investigators of the Programa Ramón y Cajal and C.F.-M. is a doctoral fellow from the MCYT (Spain)es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsclosedAccesses_ES
dc.subjectDevelopmentes_ES
dc.subjectDouble mutant micees_ES
dc.subjectLunges_ES
dc.subjectOssificationes_ES
dc.subjectMusclees_ES
dc.subjectOlfactory bulbes_ES
dc.subjectInsulin-like growth factor Ies_ES
dc.subjectLeukemia inhibitory factores_ES
dc.subjectSp3es_ES
dc.subjectTTF-Ies_ES
dc.subjectSurfactant protein Bes_ES
dc.titleDevelopmental cooperation of leukemia inhibitory factor and insulin-like growth factor I in mice is tissue-specific and essential for lung maturation involving Sp3 and TTF-1es_ES
dc.typeArtículoes_ES
dc.identifier.doi10.1016/S0925-4773(02)00449-5-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/S0925-4773(02)00449-5es_ES
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