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Title

Magnetic and relaxation properties of multifunctional polymer-based nanostructured bioferrofluids as MRI contrast agents

AuthorsAmiri, H.; Bustamante, R.; Millán, Ángel; Silva, Nuno Joâo O.; Piñol, Rafael; Gabilondo, Lierni; Palacio, Fernando
Issue Date2011
PublisherWiley-Blackwell
CitationMagnetic Resonance in Medicine 66(6): 1715-1721 (2011)
AbstractA series of maghemite/polymer composite ferrofluids with variable magnetic core size, which show a good efficiency as MRI contrast agents, are presented. These ferrofluids are biocompatible and can be proposed as possible platforms for multifunctional biomedical applications, as they contain anchoring groups for biofunctionalization, can incorporate fluorescent dyes, and have shown low cellular toxicity. The magnetic properties of the ferrofluids have been determined by means of magnetization and ac susceptibility measurements as a function of temperature and frequency. The NMR dispersion profiles show that the low frequency behavior of the longitudinal relaxivity r1 is well described by the heuristic model of 1H nuclear relaxation induced by superparamagnetic nanoparticles proposed by Roch and co-workers. The contrast efficiency parameter, i.e., the nuclear transverse relaxivity r2, for samples with d > 10 nm assumes values comparable with or better than the ones of commercial samples, the best results obtained in particles with the biggest magnetic core, d = 15 nm. The contrast efficiency results are confirmed by in vitro MRI experiments at ν = 8.5 MHz, thus allowing us to propose a set of optimal microstructural parameters for multifunctional ferrofluids to be used in MRI medical diagnosis. Copyright © 2011 Wiley Periodicals, Inc.
URIhttp://hdl.handle.net/10261/53079
DOI10.1002/mrm.22959
Identifiersdoi: 10.1002/mrm.22959
issn: 0740-3194
e-issn: 1522-2594
Appears in Collections:(ICMA) Artículos
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