English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/53048
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement

AuthorsLópez-Atalaya, José P.; Ciccarelli, Alessandro; Viosca, José; Valor, Luis Miguel; Jiménez-Minchan, María; Canals Gamoneda, Santiago; Giustetto, Maurizio; Barco, Ángel
Issue Date2011
PublisherNature Publishing Group
CitationEMBO Journal 30(20): 4287-4298 (2011)
AbstractThe epigenetic changes of the chromatin represent an attractive molecular substrate for adaptation to the environment. We examined here the role of CREB-binding protein (CBP), a histone acetyltransferase involved in mental retardation, in the genesis and maintenance of long-lasting systemic and behavioural adaptations to environmental enrichment (EE). Morphological and behavioural analyses demonstrated that EE ameliorates deficits associated to CBP deficiency. However, CBP-deficient mice also showed a strong defect in environment-induced neurogenesis and impaired EE-mediated enhancement of spatial navigation and pattern separation ability. These defects correlated with an attenuation of the transcriptional programme induced in response to EE and with deficits in histone acetylation at the promoters of EE-regulated, neurogenesis-related genes. Additional experiments in CBP restricted and inducible knockout mice indicated that environment-induced adult neurogenesis is extrinsically regulated by CBP function in mature granule cells. Overall, our experiments demonstrate that the environment alters gene expression by impinging on activities involved in modifying the epigenome and identify CBP-dependent transcriptional neuroadaptation as an important mediator of EE-induced benefits, a finding with important implications for mental retardation therapeutics. © 2011 European Molecular Biology Organization | All Rights Reserved.
Identifiersdoi: 10.1038/emboj.2011.299
issn: 0261-4189
e-issn: 1460-2075
Appears in Collections:(IN) Artículos
Files in This Item:
File Description SizeFormat 
CBP.pdf10,52 MBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.