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Title

Improved Microwave-Assisted Ring Opening of 1,1,1-Trifluoro-2,3-epoxypropane: Synthesis of New 3-Alkoxy-1,1,1-trifluoropropan-2-ols

AuthorsRayo, Josep; Muñoz, Lourdes ; Rosell, Gloria ; Bosch, María Pilar ; Guerrero, Ángel
Keywords1,1,1-trifluoro-2
3-epoxypropane
ring opening
tri­fluoro­methyl carbinols
trifluoromethyl ketones
microwave catalysis
Issue Date2010
PublisherThieme
Thieme
CitationSynthesis - Journal of Synthetic Organic Chemistry
AbstractA highly efficient and environmentally friendly method for the synthesis of 3-alkoxy-1,1,1-trifluoropropan-2-ols is presented. The approach involves ring-opening reaction of 1,1,1-trifluoro-2,3-epoxypropane with structurally different long-chain alcohols under microwave irradiation at room temperature in the absence of solvent. These chemicals are precursors of the corresponding tri­fluoromethyl ketones, potent inhibitors of human and murine liver microsomes and porcine liver esterase.
Publisher version (URL)http://dx.doi.org/10.1055/s-0030-1258156
URIhttp://hdl.handle.net/10261/53047
DOI10.1055/s-0030-1258156
ISSN0039-7881
E-ISSN1437-210X
Appears in Collections:(IQAC) Artículos
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