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Título: | Canoe functions at the CNS midline glia in a complex with Shotgun and Wrapper-Nrx-IV during neuron-glia interactions |
Autor: | Slováková, Jana CSIC; Carmena, Ana CSIC ORCID | Fecha de publicación: | 2011 | Editor: | Company of Biologists | Citación: | Development 138(8): 1563-1571 (2011) | Resumen: | Vertebrates and insects alike use glial cells as intermediate targets to guide growing axons. Similar to vertebrate oligodendrocytes, Drosophila midline glia ensheath and separate axonal commissures. Neuron-glia interactions are crucial during these events, although the proteins involved remain largely unknown. Here, we show that Canoe (Cno), the Drosophila ortholog of AF-6, and the DE-cadherin Shotgun (Shg) are highly restricted to the interface between midline glia and commissural axons. cno mutant analysis, genetic interactions and co-immunoprecipitation assays unveil Cno function as a novel regulator of neuronglia interactions, forming a complex with Shg, Wrapper and Neurexin IV, the homolog of vertebrate Caspr/paranodin. Our results also support additional functions of Cno, independent of adherens junctions, as a regulator of adhesion and signaling events in non-epithelial tissues. © 2011. Published by The Company of Biologists Ltd. | URI: | http://hdl.handle.net/10261/53046 | DOI: | 10.1242/dev.056192 | Identificadores: | doi: 10.1242/dev.056192 issn: 0950-1991 e-issn: 1477-9129 |
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Canoe functions at the CNS.pdf | 5,1 MB | Adobe PDF | Visualizar/Abrir |
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