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Title

Gene regulation by MAPK substrate competition

AuthorsAndreu, María José ; Jiménez, Gerardo ; Shvartsman, Stanislav Y.
Issue Date2011
PublisherElsevier
CitationDevelopmental Cell 20(6): 880-887 (2011)
AbstractDeveloping tissues are patterned by coordinated activities of signaling systems, which can be integrated by a regulatory region of a gene that binds multiple transcription factors or by a transcription factor that is modified by multiple enzymes. Based on a combination of genetic and imaging experiments in the early Drosophila embryo, we describe a signal integration mechanism that cannot be reduced to a single gene regulatory element or a single transcription factor. This mechanism relies on an enzymatic network formed by mitogen-activated protein kinase (MAPK) and its substrates. Specifically, anteriorly localized MAPK substrates, such as Bicoid, antagonize MAPK-dependent downregulation of Capicua, a repressor that is involved in gene regulation along the dorsoventral axis of the embryo. MAPK substrate competition provides a basis for ternary interaction of the anterior, dorsoventral, and terminal patterning systems. A mathematical model of this interaction can explain gene expression patterns with both anteroposterior and dorsoventral polarities. © 2011 Elsevier Inc.
DescriptionEl pdf del artículo es el manuscrito de autor (PMID:21664584).-- et al.
Publisher version (URL)http://dx.doi.org/10.1016/j.devcel.2011.05.009
URIhttp://hdl.handle.net/10261/53035
DOI10.1016/j.devcel.2011.05.009
Identifiersdoi: 10.1016/j.devcel.2011.05.009
issn: 1534-5807
e-issn: 1878-1551
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