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A small cytoplasmic region adjacent to the fourth transmembrane segment of the α7 nicotinic receptor is essential for its biogenesis

AuthorsCriado, Manuel CSIC ORCID; Mulet Soler, José; Gerber, Susana; Sala, Salvador; Sala, Francisco
Issue Date2011
CitationFEBS Letters 585: 2477-2480 (2011)
AbstractDeletion of a small cytoplasmic fragment close to the fourth transmembrane segment of the nicotinic α7 receptor (Glu437 to Arg447) abolished membrane expression. Different single mutants showed moderate to strong decreases in expression whereas the latter was totally abolished upon proline substitutions. We hypothesize that preservation of an α-helix formed by the fourth transmembrane segment and the adjacent cytoplasmic region is essential for membrane receptor expression. Moreover, in selected mutants with low or null membrane expression, a significant proportion of mature receptors was present inside the cell. Hence, elements in this cytoplasmic fragment might influence receptor transport to the membrane. © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Identifiersdoi: 10.1016/j.febslet.2011.06.028
issn: 0014-5793
e-issn: 1873-3468
Appears in Collections:(IN) Artículos
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