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Title

Function and regulation of Saccharomyces cerevisiae myosins-I in endocytic budding

AuthorsGiblin, Jonathan; Fernández-Golbano, Isabel María ; Idrissi, Fátima-Zahra ; Geli, María Isabel
Issue Date2011
PublisherBiochemical Society
CitationBiochemical Society Transactions 39(5): 1185-1190 (2011)
AbstractMyosins-I are widely expressed actin-dependent motors which bear a phospholipid-binding domain. In addition, some members of the family can trigger Arp2/3 complex (actin-related protein 2/3 complex)-dependent actin polymerization. In the early 1990s, the development of powerful genetic tools in protozoa and mammals and discovery of these motors in yeast allowed the demonstration of their roles in membrane traffic along the endocytic and secretory pathways, in vacuole contraction, in cell motility and in mechanosensing. The powerful yeast genetics has contributed towards dissecting in detail the function and regulation of Saccharomyces cerevisiae myosins-IMyo3 and Myo5 in endocytic budding from the plasma membrane. In the present review, we summarize the evidence, dissecting their exact role in membrane budding and the molecular mechanisms controlling their recruitment and biochemical activities at the endocytic sites. ©The Authors Journal compilation ©2011 Biochemical Society.
URIhttp://hdl.handle.net/10261/53007
DOIhttp://dx.doi.org/10.1042/BST0391185
Identifiersdoi: 10.1042/BST0391185
issn: 0300-5127
e-issn: 1470-8752
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