English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/52871
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

In situ photopolymerization of biomaterials by thiol-yne click chemistry

AuthorsLomba, Miguel; Oriol, Luis; Alcalá, Rafael; Sánchez-Somolinos, Carlos; Grazú, Valeria; Serrano, José Luis; Fuente, Jesús M. de la
Issue Date2011
PublisherWiley-VCH
CitationMacromolecular Bioscience 11(11): 1505-1514 (2011)
AbstractThe thiol-yne click chemistry reaction has been used for the in situ photocrosslinking of an aliphatic hyperbranched polyester. The biocompatibility of the resulting networks has been studied and marked cytotoxicity was not found for HeLa (human cervical carcinoma) tumoral cells and COS7 fibroblasts. The photoinduced thiol-yne process allows the generation of patterned structures with different geometries in films by DLW and these materials can be used as substrates for cell adhesion. The influence of the substrate geometry on cell adhesion has been studied by culturing cells onto these substrates and a preference for the photopatterned polymeric material can be seen in some of the structures by contrast phase microscopy. Actin and vinculin fluorescent staining revealed different adhesion behavior for HeLa cells and COS7 fibroblasts and this could be assigned to the different motility of cells. The thiol-yne photoreaction has proven to be an attractive approach for the preparation of micropatterned biomaterials.
URIhttp://hdl.handle.net/10261/52871
DOI10.1002/mabi.201100123
Identifiersdoi: 10.1002/mabi.201100123
issn: 1616-5187
e-issn: 1616-5195
Appears in Collections:(ICMA) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.