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Title

cAMP response element-binding protein is a primary hub of activity-driven neuronal gene expression

AuthorsBenito, Eva; Valor, Luis Miguel; Jiménez-Minchan, María; Huber, Wolfgang; Barco, Ángel
Issue Date2011
PublisherSociety for Neuroscience
CitationJournal of Neuroscience 31(50): 18237-18250 (2011)
AbstractLong-lasting forms of neuronal plasticity require de novo gene expression, but relatively little is known about the events that occur genome-wide in response to activity in a neuronal network. Here, we unveil the gene expression programs initiated in mouse hippocampal neurons in response to different stimuli and explore the contribution of four prominent plasticity-related transcription factors (CREB, SRF, EGR1, and FOS) to these programs. Our study provides a comprehensive view of the intricate genetic networks and interactions elicited by neuronal stimulation identifying hundreds of novel downstream targets, including novel stimulus-associated miRNAs and candidate genes that may be differentially regulated at the exon/promoter level. Our analyses indicate that these four transcription factors impinge on similar biological processes through primarily non-overlapping gene-expression programs. Meta-analysis of the datasets generated in our study and comparison with publicly available transcriptomics data revealed the individual and collective contribution of these transcription factors to different activity-driven genetic programs. In addition, both gain-and loss-of-function experiments support a pivotal role for CREB in membrane-to-nucleus signal transduction in neurons. Our data provide a novel resource for researchers wanting to explore the genetic pathways associated with activity-regulated neuronal functions. © 2011 the authors.
URIhttp://hdl.handle.net/10261/52844
DOI10.1523/JNEUROSCI.4554-11.2011
Identifiersdoi: 10.1523/JNEUROSCI.4554-11.2011
issn: 0270-6474
e-issn: 1529-2401
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