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Título: | Improved synthesis of disaccharides with Escherichia coli β-galactosidase using bio-solvents derived from glycerol |
Autor: | Pérez-Sánchez, María; Cortés Cabrera, Álvaro CSIC ORCID; García-Marín, Héctor CSIC; Sinisterra, José Vicente; García, José I. CSIC ORCID ; Hernáiz, María J. | Fecha de publicación: | 2011 | Editor: | Elsevier | Citación: | Tetrahedron 67(40): 7708-7712 (2011) | Resumen: | A noticeably increase in activity, keeping total regioselectivity was found in the synthetic behaviour of Escherichia coli β-galactosidase in glycerol-based solvents using a 1:7 molar ratio of donor (pNP-β-Gal): acceptor (GlcNAc). Yields of up to 97% of β(1→6) with different solvents were found. These reactions take place without noticeable hydrolytic activity and with total regioselectivity, representing a considerable improvement over the use of aqueous buffer or conventional organic solvents. There is a clear dependence of the catalytic results on the solvent structure, which is analysed in terms of polarity and hydrophobicity. © 2011 Elsevier Ltd. All rights reserved. | URI: | http://hdl.handle.net/10261/52837 | DOI: | 10.1016/j.tet.2011.08.009 | Identificadores: | doi: 10.1016/j.tet.2011.08.009 issn: 0040-4020 |
Aparece en las colecciones: | (CBM) Artículos (ICMA) Artículos |
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