English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/52632
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease

AuthorsGangoiti, Patricia; Camacho, Luz; Arana, Lide; Ouro, Alberto; Granado, María H.; Brizuela, Leyre; Casas, Josefina; Fabriàs, Gemma; Abad, José Luis; Delgado, Antonio; Gómez-Muñoz, Antonio
KeywordsApoptosis
Cell proliferation
Ceramides
Ceramide kinase
Ceramide-1-phosphate
Ceramidases
Sphingosine kinase
Inflammation
Migration
Sphingolipids
Sphingosine 1-phosphate
Sphingomyelinases
Issue Date2010
PublisherElsevier
CitationProgress in Lipid Research
AbstractSimple bioactive sphingolipids include ceramide, sphingosine and their phosphorylated forms sphingosine 1-phosphate and ceramide 1-phosphate. These molecules are crucial regulators of cell functions. In particular, they play important roles in the regulation of angiogenesis, apoptosis, cell proliferation, differentiation, migration, and inflammation. Decoding the mechanisms by which these cellular functions are regulated requires detailed understanding of the signaling pathways that are implicated in these processes. Most importantly, the development of inhibitors of the enzymes involved in their metabolism may be crucial for establishing new therapeutic strategies for treatment of disease.
Publisher version (URL)http://dx.doi.org/10.1016/j.plipres.2010.02.004
URIhttp://hdl.handle.net/10261/52632
DOI10.1016/j.plipres.2010.02.004
ISSN0163-7827
E-ISSN1873-2194
Appears in Collections:(IQAC) Artículos
Files in This Item:
There are no files associated with this item.
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.