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Title

The immune boundaries for stem cell based therapies: Problems and prospective solutions

AuthorsHmadcha, Abdelkrim ; Domínguez-Bendala, Juan; Wakeman, Jane; Arredouani, Mohamed; Soria Escoms, Bernat
KeywordsStem cells
Histocompatibility
Immune rejection
Cell therapies
Issue DateAug-2009
PublisherJohn Wiley & Sons
CitationJournal of Cellular and Molecular Medicine 13(8a): 1464-1475 (2009)
AbstractStem cells have fascinated the scientific and clinical communities for over a century. Despite the controversy that surrounds this field, it is clear that stem cells have the potential to revolutionize medicine. However, a number of significant hurdles still stand in the way of the realization of this potential. Chiefly among these are safety concerns, differentiation efficiency and overcoming immune rejection. Here we review current progress made in this field to optimize the safe use of stem cells with particular emphasis on prospective interventions to deal with challenges generated by immune rejection. © 2009 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd.
URIhttp://hdl.handle.net/10261/52541
DOI10.1111/j.1582-4934.2009.00837.x
Identifiersdoi: 10.1111/j.1582-4934.2009.00837.x
issn: 1582-1838
Appears in Collections:(CABIMER) Artículos
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