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The immune boundaries for stem cell based therapies: Problems and prospective solutions

AutorHmadcha, Abdelkrim ; Domínguez-Bendala, Juan; Wakeman, Jane; Arredouani, Mohamed; Soria Escoms, Bernat
Palabras claveStem cells
Immune rejection
Cell therapies
Fecha de publicaciónago-2009
EditorJohn Wiley & Sons
CitaciónJournal of Cellular and Molecular Medicine 13(8a): 1464-1475 (2009)
ResumenStem cells have fascinated the scientific and clinical communities for over a century. Despite the controversy that surrounds this field, it is clear that stem cells have the potential to revolutionize medicine. However, a number of significant hurdles still stand in the way of the realization of this potential. Chiefly among these are safety concerns, differentiation efficiency and overcoming immune rejection. Here we review current progress made in this field to optimize the safe use of stem cells with particular emphasis on prospective interventions to deal with challenges generated by immune rejection. © 2009 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd.
Identificadoresdoi: 10.1111/j.1582-4934.2009.00837.x
issn: 1582-1838
ReferenciasPMID: 19583810
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