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Título

Taurine supplementation modulates glucose homeostasis and islet function

AutorCarneiro, Everardo M.; Latorraca, Marcia Q.; Araújo, Eliana; Beltrá, Marta; Oliveras-López, María Jesús; Navarro, Mónica ; Berná, Genoveva; Bedoya Bergua, Francisco Javier ; Velloso, Licio A.; Soria Escoms, Bernat ; Martín, Franz
Palabras claveDiabetes
Insulin sensitivity
Blood glucose homeostasis
Amino acids
Fecha de publicaciónjul-2009
EditorElsevier
CitaciónJournal of Nutritional Biochemistry 20(7): 503-511 (2009)
ResumenTaurine is a conditionally essential amino acid for human that is involved in the control of glucose homeostasis; however, the mechanisms by which the amino acid affects blood glucose levels are unknown. Using an animal model, we have studied these mechanisms. Mice were supplemented with taurine for 30 d. Blood glucose homeostasis was assessed by intraperitoneal glucose tolerance tests (IPGTT). Islet cell function was determined by insulin secretion, cytosolic Ca2+ measurements and glucose metabolism from isolated islets. Islet cell gene expression and translocation was examined via immunohistochemistry and quantitative real-time polymerase chain reaction. Insulin signaling was studied by Western blot. Islets from taurine-supplemented mice had: (i) significantly higher insulin content, (ii) increased insulin secretion at stimulatory glucose concentrations, (iii) significantly displaced the dose-response curve for glucose-induced insulin release to the left, (iv) increased glucose metabolism at 5.6 and 11.1-mmol/L concentrations; (v) slowed cytosolic Ca2+ concentration ([Ca2+]i) oscillations in response to stimulatory glucose concentrations; (vi) increased insulin, sulfonylurea receptor-1, glucokinase, Glut-2, proconvertase and pancreas duodenum homeobox-1 (PDX-1) gene expression and (vii) increased PDX-1 expression in the nucleus. Moreover, taurine supplementation significantly increased both basal and insulin stimulated tyrosine phosphorylation of the insulin receptor in skeletal muscle and liver tissues. Finally, taurine supplemented mice showed an improved IPGTT. These results indicate that taurine controls glucose homeostasis by regulating the expression of genes required for glucose-stimulated insulin secretion. In addition, taurine enhances peripheral insulin sensitivity.
URIhttp://hdl.handle.net/10261/52516
DOI10.1016/j.jnutbio.2008.05.008
Identificadoresissn: 0955-2863
ReferenciasPMID: 18708284
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