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dc.contributor.authorBartolomé Robledo, Fernando-
dc.contributor.authorMuñoz, Úrsula-
dc.contributor.authorEsteras, Noemí-
dc.contributor.authorAlquézar, Carolina-
dc.contributor.authorCollado, Andrea-
dc.contributor.authorBermejo-Pareja, Félix-
dc.contributor.authorMartín-Requero, Ángeles-
dc.date.issued2010-07-08-
dc.identifier.citationCellular and Molecular Life Sciences 67(24):4257-4268(2010)es_ES
dc.identifier.issn1420-682X-
dc.identifier.urihttp://hdl.handle.net/10261/52414-
dc.description12 páginas, 9 figuras, 1 tabla -- PAGS nros. 4268-4257es_ES
dc.description.abstractStatins may exert beneficial effects on Alzheimer’s disease (AD) patients. Based on the antineoplastic and apoptotic effects of statins in a number of cell types, we hypothesized that statins may be able to protect neurons by controlling the regulation of cell cycle and/or apoptosis. A growing body of evidence indicates that neurodegeneration involves the cell-cycle activation in postmitotic neurons. Failure of cell-cycle control is not restricted to neurons in AD patients, but occurs in peripheral cells as well. For these reasons, we studied the role of simvastatin (SIM) on cell survival/death in lymphoblasts from AD patients. We report here that SIM induces apoptosis in AD lymphoblasts deprived of serum. SIM interacts with PI3K/Akt and ERK1/2 signaling pathways thereby decreasing the serum withdrawal-enhanced levels of the CDK inhibitor p21Cip1 (p21) and restoring the vulnerability of AD cells to trophic factor deprivationes_ES
dc.description.sponsorshipThis work was supported by grants from the Ministry of Education and Science (SAF2007-62405) and Fundación Eugenio Rodríguez Pascual. NE holds a fellowship of the JAE predoctoral program of the CSIC. CA was the recipient of a fellowship from the Launching Grants Program of the CIBERERes_ES
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.rightsclosedAccesses_ES
dc.subjectAlzheimer’s diseasees_ES
dc.subjectLymphocyteses_ES
dc.subjectSimvastatines_ES
dc.subjectp21es_ES
dc.subjectPI3K/Aktes_ES
dc.subjectERK1/2es_ES
dc.titleSimvastatin overcomes the resistance to serum withdrawal-induced apoptosis of lymphocytes from Alzheimer´s disease patientses_ES
dc.typeartículoes_ES
dc.identifier.doihttp://dx.doi.org/10.1007/s00018-010-0443-2-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1007/s00018-010-0443-2es_ES
dc.identifier.e-issn1420-9071-
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