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dc.contributor.authorCarrasco-Rando, Marta-
dc.contributor.authorTutor, Antonio S.-
dc.contributor.authorPrieto-Sánchez, Silvia-
dc.contributor.authorGonzález-Pérez, Esther-
dc.contributor.authorBarrios, Natalia-
dc.contributor.authorLetizia, Annalisa-
dc.contributor.authorMartín, Paloma-
dc.contributor.authorCampuzano, Sonsoles-
dc.contributor.authorRuiz-Gómez, Mar-
dc.identifierdoi: 10.1371/journal.pgen.1002186-
dc.identifierissn: 1553-7390-
dc.identifiere-issn: 1553-7404-
dc.identifier.citationPLoS Genetics 7(7): e1002186 (2011)-
dc.descriptionThis is an open-access article distributed under the terms of the Creative Commons Attribution License.-
dc.description.abstractA central issue of myogenesis is the acquisition of identity by individual muscles. In Drosophila, at the time muscle progenitors are singled out, they already express unique combinations of muscle identity genes. This muscle code results from the integration of positional and temporal signalling inputs. Here we identify, by means of loss-of-function and ectopic expression approaches, the Iroquois Complex homeobox genes araucan and caupolican as novel muscle identity genes that confer lateral transverse muscle identity. The acquisition of this fate requires that Araucan/Caupolican repress other muscle identity genes such as slouch and vestigial. In addition, we show that Caupolican-dependent slouch expression depends on the activation state of the Ras/Mitogen Activated Protein Kinase cascade. This provides a comprehensive insight into the way Iroquois genes integrate in muscle progenitors, signalling inputs that modulate gene expression and protein activity. © 2011 Carrasco-Rando et al.-
dc.description.sponsorshipThis work was supported by a JAE-Doc contract to AST; grants BFU2007-62201, BFU2008-03762/BMC, BFU2010-14884/BMC, CSIC/201020E094, and CONSOLIDER CDS2007-00008 from MEC to MR-G and SC; LSHG-CT-2004-511978 from the EC to the Network of Excellence MYORES; and an institutional grant from Fundación Ramón Areces to the CBMSO.-
dc.publisherPublic Library of Science-
dc.relation.isversionofPublisher’s version-
dc.titleDrosophila araucan and caupolican integrate intrinsic and signalling inputs for the acquisition by muscle progenitors of the lateral transverse fate-
dc.description.versionPeer Reviewed-
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)-
dc.contributor.funderMinisterio de Educación y Ciencia (España)-
dc.contributor.funderEuropean Commission-
dc.contributor.funderFundación Ramón Areces-
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