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The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators

AuthorsGarcía-Gutiérrez, Pablo ; Juárez-Vicente, Francisco ; Gallardo-Chamizo, Francisco ; Charnay, Patrick; García-Domínguez, Mario
SUMO ligase
Issue Date3-Sep-2011
PublisherNature Publishing Group
CitationEMBO Reports 12(10): 1018-1023 (2011)
AbstractCovalent attachment of small ubiquitin-like modifier (SUMO) to proteins regulates many processes in the eukaryotic cell. This reaction is similar to ubiquitination and usually requires an E3 ligase for substrate modification. However, only a few SUMO ligases have been described so far, which frequently facilitate sumoylation by bringing together the SUMO-conjugating enzyme Ubc9 and the target protein. Ubc9 is an interaction partner of the transcription factor Krox20, a key regulator of hindbrain development. Here, we show that Krox20 functions as a SUMO ligase for its coregulators-the Nab proteins-and that Nab sumoylation negatively modulates Krox20 transcriptional activity in vivo. © 2011 EuropeEan MoleEcular Biology Oorganization.
Publisher version (URL)http://dx.doi.org/10.1038/embor.2011.152
Identifiersissn: 1469-221X
Appears in Collections:(CABIMER) Artículos
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