English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/52299
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Antiproliferative Activity of Gold(I) Alkyne Complexes Containing Water-Soluble Phosphane Ligands

AuthorsVergara, Elena; Cerrada, Elena ; Laguna, Mariano
Issue Date2010
PublisherAmerican Chemical Society
CitationOrganometallics 29(11): 2596-2603 (2010)
AbstractA series of mono-, di-, and trinuclear organometallic alkynyl phosphane gold(I) complexes containing the stable and water-soluble PTA and DAPTA ligands have been synthesized and characterized. The solid-state structure of one of these compounds was also established by X-ray crystallography. Luminiscence was observed for most of these Au(I) alkynyl derivatives in the solid state. The cytotoxicity of the complexes was evaluated on A2780 ovarian cancer cells and on their cisplatin-resistant cell line A2780cisR; the compounds showed an activity in the low μM range, being markedly more active than cisplatin in the A2780cisR cell line. The intracellular distribution of some representative compounds was determined using epifluorescence microscopy. The presented results are discussed in relation to the putative mechanism of action of this family of gold-based cytotoxic agents.
Identifiersdoi: 10.1021/om100300a
issn: 0276-7333
e-issn: 1520-6041
Appears in Collections:(ICMA) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.