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Title

Access to the cis-fused stereoisomers of proline analogues containing an octahydroindole core

AuthorsSayago, Francisco J. ; Laborda, Pedro ; Calaza, M. Isabel ; Jiménez, Ana I. ; Cativiela, Carlos
Issue Date2011
PublisherWiley-VCH
CitationEuropean Journal of Organic Chemistry 11: 2011-2028 (2011)
AbstractAn overview of the synthetic methods developed to build all the cis-fused stereoisomers of octahydroindole-2-carboxylic acid and its α-methylated derivative in enantiomerically pure form is presented. Both asymmetric synthetic strategies(auxiliary- or substrate-controlled processes) and procedures based on the resolution of racemic compounds (chemical, enzymatic, and chromatographic processes) are summarized. Special emphasis has been placed on those strategies able to provide multigram quantities of enantiopure compounds, a prerequisite to make downstream biological applications feasible.
DescriptionEl pdf del artículo es la versión post-print.
Publisher version (URL)http://dx.doi.org/10.1002/ejoc.201001710
URIhttp://hdl.handle.net/10261/52165
DOI10.1002/ejoc.201001710
Identifiersdoi: 10.1002/ejoc.201001710
issn: 1434-193X
e-issn: 1099-0690
Appears in Collections:(ICMA) Artículos
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