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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/52152
Título

Transcriptomics throughout the life cycle of Leishmania infantum: high down-regulation rate in the amastigote stage

AutorAlcolea, Pedro J. ; Alonso, Ana ; Gómez, Manuel José ; Moreno, Inmaculada; Domínguez, Mercedes; Parro, Víctor; Larraga, Vicente
Palabras claveLeishmania infantum
Life cycle
Genomic DNA microarrays
Amastigote
Down-regulation
Fecha de publicaciónnov-2010
EditorElsevier
CitaciónInternational Journal for Parasitology 40(13):1497-1516(2010)
ResumenLeishmania infantum is the causative agent of zoonotic visceral leishmaniasis in the Mediterranean Basin. The promastigote and amastigote stages alternate in the life cycle of the parasite, developing inside the sand-fly gut and inside mammalian phagocytic cells, respectively. High-throughput genomic and proteomic analyses have not focused their attention on promastigote development, although partial approaches have been made in Leishmania major and Leishmania braziliensis. For this reason we have studied the expression modulation of an etiological agent of visceral leishmaniasis throughout the life cycle, which has been performed by means of complete genomic microarrays. In the context of constitutive genome expression in Leishmania spp. described elsewhere and confirmed here (5.7%), we found a down-regulation rate of 68% in the amastigote stage, which has been contrasted by binomial tests and includes the down-regulation of genes involved in translation and ribosome biogenesis. These findings are consistent with the hypothesis of pre-adaptation of the parasite to intracellular survival at this stage
Descripción20 páginas, 5 figuras, 5 tablas -- PAGS nros. 1497-1516
Versión del editorhttp://dx.doi.org/10.1016/j.ijpara.2010.05.013
URIhttp://hdl.handle.net/10261/52152
DOI10.1016/j.ijpara.2010.05.013
ISSN0020-7519
E-ISSN1879-0135
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