Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/52031
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Canonical BMP7 activity is required for the generation of discrete neuronal populations in the dorsal spinal cord |
Autor: | Dréau, G. le CSIC ORCID ; García-Campmany, Lidia CSIC; Rabadán, M. Ángeles; Ferronha, Tiago; Tozer, Samuel; Briscoe, James; Martí, Elisa CSIC ORCID | Fecha de publicación: | 2012 | Editor: | Company of Biologists | Citación: | Development 139(2): 259-268 (2012) | Resumen: | BMP activity is essential for many steps of neural development, including the initial role in neural induction and the control of progenitor identities along the dorsal-ventral axis of the neural tube. Taking advantage of chick in ovo electroporation, we show a novel role for BMP7 at the time of neurogenesis initiation in the spinal cord. Using in vivo loss-of-function experiments, we show that BMP7 activity is required for the generation of three discrete subpopulations of dorsal interneurons: dI1-dI3-dI5. Analysis of the BMP7 mouse mutant shows the conservation of this activity in mammals. Furthermore, this BMP7 activity appears to be mediated by the canonical Smad pathway, as we demonstrate that Smad1 and Smad5 activities are similarly required for the generation of dI1-dI3-dI5. Moreover, we show that this role is independent of the patterned expression of progenitor proteins in the dorsal spinal cord, but depends on the BMP/Smad regulation of specific proneural proteins, thus narrowing this BMP7 activity to the time of neurogenesis. Together, these data establish a novel role for BMP7 in primary neurogenesis, the process by which a neural progenitor exits the cell cycle and enters the terminal differentiation pathway. © 2012. Published by The Company of Biologists Ltd. | URI: | http://hdl.handle.net/10261/52031 | DOI: | 10.1242/dev.074948 | Identificadores: | doi: 10.1242/dev.074948 issn: 0950-1991 e-issn: 1477-9129 |
Aparece en las colecciones: | (IBMB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
40
checked on 19-abr-2024
SCOPUSTM
Citations
64
checked on 21-abr-2024
WEB OF SCIENCETM
Citations
59
checked on 23-feb-2024
Page view(s)
379
checked on 23-abr-2024
Download(s)
111
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.