English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/51887
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Shugoshin-2 is essential for the completion of meiosis but not for mitotic cell division in mice

AutorLlano, Elena ; Gutiérrez-Caballero, Cristina; Herrán, Yurema ; Sánchez-Martín, M.; Vázquez-Quiñones, Luis; Hernández, M. Teresa ; Álava, Enrique de ; Cuadrado, Ana ; Barbero, José Luis ; Pendás, Alberto M.
Palabras claveCohesion
Mitosis
Meiosis
Fecha de publicación1-sep-2008
EditorCold Spring Harbor Laboratory. Press
CitaciónGenes and Development 22: 2400-2413 (2008)
ResumenShugoshin-2 (SGOL2) is one of the two mammalian orthologs of the Shugoshin/Mei-S322 family of proteins that regulate sister chromatid cohesion by protecting the integrity of the multiprotein cohesin complexes. This protective system is essential for faithful chromosome segregation during mitosis and meiosis, which is the physical basis of Mendelian inheritance. Regardless of its evolutionary conservation from yeast to mammals, little is known about the in vivo relevance and specific role that SGOL2 plays in mammals. Here we show that disruption of the gene encoding mouse SGOL2 does not cause any alteration in sister chromatid cohesion in embryonic cultured fibroblasts and adult somatic tissues. Moreover, mutant mice develop normally and survive to adulthood without any apparent alteration. However, both male and female Sgol2 deficient mice are infertile. We demonstrate that SGOL2 is necessary for protecting centromeric cohesion during mammalian meiosis I. In vivo, the loss of SGOL2 promotes a premature release of the meiosis-specific REC8 cohesin complexes from anaphase I centromeres. This molecular alteration is manifested cytologically by the complete loss of centromere cohesion at metaphase II leading to single chromatids and physiologically with the formation of aneuploid gametes that give rise to infertility.
Descripción14 páginas, 6 figuras.-- et al.
Versión del editorhttp://dx.doi.org/10.1101/gad.475308
URIhttp://hdl.handle.net/10261/51887
DOI10.1101/gad.475308
ISSN0890-9369
Aparece en las colecciones: (CIB) Artículos
(IBMCC) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
GENESDEV-2008-096958v2-Pendas-2final.pdf2,5 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.