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dc.contributor.author | Pascual-Brazo, Jesús | - |
dc.contributor.author | Castro, Elena | - |
dc.contributor.author | Díaz, Álvaro | - |
dc.contributor.author | Valdizán, Elsa M. | - |
dc.contributor.author | Pilar-Cuéllar, Fuencisla | - |
dc.contributor.author | Vidal, Rebeca | - |
dc.contributor.author | Treceño, Begoña | - |
dc.contributor.author | Pazos, Ángel | - |
dc.date.accessioned | 2012-06-19T09:58:06Z | - |
dc.date.available | 2012-06-19T09:58:06Z | - |
dc.date.issued | 2011 | - |
dc.identifier | doi: 10.1017/S1461145711000782 | - |
dc.identifier | issn: 1461-1457 | - |
dc.identifier.citation | International Journal of Neuropsychopharmacology 15(5): 631-643 (2011) | - |
dc.identifier.uri | http://hdl.handle.net/10261/51831 | - |
dc.description.abstract | It has been recently suggested that activation of 5-HT4 receptors might exert antidepressant-like effects in rats after 3 d treatment, suggesting a new strategy for developing faster-acting antidepressants. We studied the effects of 3 d and 7 d treatment with the 5-HT4 receptor partial agonist RS67333 (1.5 mg/kg.d) in behavioural tests of chronic efficacy and on neuroplastic-associated changes, such as adult hippocampal neurogenesis, expression of CREB, BDNF, ß-catenin, AKT and 5-HT4 receptor functionality. RS67333 treatment up-regulated hippocampal cell proliferation, ß-catenin expression and pCREB/CREB ratio after 3 d treatment. This short-term treatment also reduced immobility time in the forced swim test (FST), together with a partial reversion of the anhedonic-like state (sucrose consumption after chronic corticosterone). Administration of RS67333 for 7 d resulted in a higher increase in the rate of hippocampal cell proliferation, a significant desensitization of 5-HT4 receptor-coupled adenylate cyclase activity and a more marked increase in the expression of neuroplasticity-related proteins (BDNF, CREB, AKT): these changes reached the same magnitude as those observed after 3 wk administration of classical antidepressants. Consistently, a positive behavioural response in the novelty suppressed feeding (NSF) test and a complete reversion of the anhedonic-like state (sucrose consumption) were also observed after 7 d treatment. These results support the antidepressant-like profile of RS67333 with a shorter onset of action and suggest that this time period of administration (3-7 d) could be a good approximation to experimentally predict the onset of action of this promising strategy. | - |
dc.description.sponsorship | This work was supported by Ministerio de Ciencia e Innovación (SAF-07/61862), Fundación Alicia Koplowitz and Fundación de Investigación Médica Mutua Madrileña. | - |
dc.language.iso | eng | - |
dc.publisher | Cambridge University Press | - |
dc.rights | openAccess | - |
dc.title | Modulation of neuroplasticity pathways and antidepressant-like behavioural responses following the short-term (3 and 7 days) administration of the 5-HT4 receptor agonist RS67333 | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1017/S1461145711000782 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1017/S1461145711000782 | - |
dc.date.updated | 2012-06-19T09:58:06Z | - |
dc.description.version | Peer Reviewed | - |
dc.identifier.pmid | 21733238 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
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