English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/5159
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Citado 35 veces en Web of Knowledge®  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)
Título : Novel Rho GTPase Involved in Cytokinesis and Cell Wall Integrity in the Fission Yeast Schizosaccharomyces pombe
Autor : Santos Romero, Beatriz; Pérez González, Pilar; Gutiérrez, Javier; Mateo Calonge, María Teresa
Fecha de publicación : jun-2003
Editor: American Society for Microbiology
Citación : Eukaryot Cell 2(3): 521–533 (2003)
Resumen: The Rho family of GTPases is present in all eukaryotic cells from yeast to mammals; they are regulators in signaling pathways that control actin organization and morphogenetic processes. In yeast, Rho GTPases are implicated in cell polarity processes and cell wall biosynthesis. It is known that Rho1 and Rho2 are key proteins in the construction of the cell wall, an essential structure that in Schizosaccharomyces pombe is composed of β-glucan, α-glucan, and mannoproteins. Rho1 regulates the synthesis of 1,3-β-d-glucan by activation of the 1,3-β-d-glucan synthase, and Rho2 regulates the synthesis of α-glucan by the 1,3-α-d-glucan synthase Mok1. Here we describe the characterization of another Rho GTPase in fission yeast, Rho4. rho4Δ cells are viable but display cell separation defects at high temperature. In agreement with this observation, Rho4 localizes to the septum. Overexpression of rho4+ causes lysis and morphological defects. Several lines of evidence indicate that both rho4+ deletion or rho4+ overexpression result in a defective cell wall, suggesting an additional role for Rho4 in cell wall integrity. rho4Δ cells also accumulate secretory vesicles around the septum and are defective in actin polarization. We propose that Rho4 could be involved in the regulation of the septum degradation during cytokinesis.
Versión del editor: http://dx.doi.org/10.1128/EC.2.3.521-533.2003
URI : http://hdl.handle.net/10261/5159
DOI: 10.1128/EC.2.3.521-533.2003
ISSN: 1535-9778
Aparece en las colecciones: (IMB) Artículos
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro completo
 



NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.