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The FN3 and BRCT motifs in the exomer component Chs5p define a conserved module that is necessary and sufficient for its function

AutorMartín-García, Rebeca ; León, Nagore de; Sharifmoghadam, M. R.; Curto, María Ángeles; Hoya, Marta; Bustos-Sanmamed, P.; Valdivieso, María Henar
Fecha de publicación2011
EditorSpringer
CitaciónCellular and Molecular Life Sciences 68(17): 2907-2917 (2011)
ResumenChs5p is a component of the exomer, a coat complex required to transport the chitin synthase Chs3p from the trans-Golgi network to the plasma membrane. The Chs5p N-terminal region exhibits fibronectin type III (FN3) and BRCT domains. FN3 domains are present in proteins that mediate adhesion processes, whereas BRCT domains are involved in DNA repair. Several fungi-including Schizosaccharomyces pombe, which has no detectable amounts of chitin-have proteins similar to Chs5p. Here we show that the FN3 and BRCT motifs in Chs5p behave as a module that is necessary and sufficient for Chs5p localization and for cargo delivery. The N-terminal regions of S. cerevisiae Chs5p and S. pombe Cfr1p are interchangeable in terms of Golgi localization, but not in terms of exomer assembly, showing that the conserved function of this module is protein retention in this organelle and that the interaction between the exomer components is organism-specific. © 2010 Springer Basel AG.
DescripciónEl pdf del artículo es la versión pre-print.
Versión del editorhttp://dx.doi.org/10.1007/s00018-010-0596-z
URIhttp://hdl.handle.net/10261/51459
DOI10.1007/s00018-010-0596-z
Identificadoresdoi: 10.1007/s00018-010-0596-z
issn: 1420-682X
e-issn: 1420-9071
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