English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/51348
Título

Tetrodotoxin as a tool to elucidate sensory transduction mechanisms: The case for the arterial chemoreceptors of the carotid body

AutorRocher, Asunción ; Cáceres, Ana Isabel; Obeso, Ana ; González, Constancio
Fecha de publicación2011
EditorMultidisciplinary Digital Publishing Institute
CitaciónMarine Drugs 9(12): 2683-2704 (2011)
ResumenCarotid bodies (CBs) are secondary sensory receptors in which the sensing elements, chemoreceptor cells, are activated by decreases in arterial PO2 (hypoxic hypoxia). Upon activation, chemoreceptor cells (also known as Type I and glomus cells) increase their rate of release of neurotransmitters that drive the sensory activity in the carotid sinus nerve (CSN) which ends in the brain stem where reflex responses are coordinated. When challenged with hypoxic hypoxia, the physiopathologically most relevant stimulus to the CBs, they are activated and initiate ventilatory and cardiocirculatory reflexes. Reflex increase in minute volume ventilation promotes CO2 removal from alveoli and a decrease in alveolar PCO2 ensues. Reduced alveolar PCO2 makes possible alveolar and arterial PO2 to increase minimizing the intensity of hypoxia. The ventilatory effect, in conjunction the cardiocirculatory components of the CB chemoreflex, tend to maintain an adequate supply of oxygen to the tissues. The CB has been the focus of attention since the discovery of its nature as a sensory organ by de Castro (1928) and the discovery of its function as the origin of ventilatory reflexes by Heymans group (1930). A great deal of effort has been focused on the study of the mechanisms involved in O2 detection. This review is devoted to this topic, mechanisms of oxygen sensing. Starting from a summary of the main theories evolving through the years, we will emphasize the nature and significance of the findings obtained with veratridine and tetrodotoxin (TTX) in the genesis of current models of O2-sensing.
Versión del editorhttp://dx.doi.org/10.3390/md9122683
URIhttp://hdl.handle.net/10261/51348
DOI10.3390/md9122683
Identificadoresdoi: 10.3390/md9122683
issn: 1660-3397
e-issn: 1660-3397
Aparece en las colecciones: (IBGM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Tetrodotoxin as a Tool to Elucidate Sensory.pdf573,85 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.