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Título

An adamantyl amino acid containing gramicidin S analogue with broad spectrum antibacterial activity and reduced hemolytic activity

AutorRaaij, Mark J. van; Overhand, Mark
Fecha de publicación2010
EditorWiley-VCH
CitaciónChemistry - A European Journal 16(40): 12174-12181 (2010)
ResumenThe cyclic cationic antimicrobial peptide gramicidin S (GS) is an effective topical antibacterial agent that is toxic for human red blood cells (hemolysis). Herein, we present a series of amphiphilic derivatives of GS with either two or four positive charges and characteristics ranging between very polar and very hydrophobic. Screening of this series of peptide derivatives identified a compound that combines effective antibacterial activity with virtually no toxicity within the same concentration range. This peptide acts against both Gram-negative and Gram-positive bacteria, including several MRSA strains, and represents an interesting lead for the development of a broadly applicable antibiotic. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Descripciónet al.
URIhttp://hdl.handle.net/10261/51343
DOI10.1002/chem.201001686
Identificadoresdoi: 10.1002/chem.201001686
issn: 0947-6539
e-issn: 1521-3765
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