English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/5129
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Citado 29 veces en Web of Knowledge®  |  Pub MebCentral Ver citas en PubMed Central  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)
Título : Activation of vav by the gammaherpesvirus M2 protein contributes to the establishment of viral latency in B lymphocytes
Autor : Rodríguez, Lénia; Pires de Miranda, Marta; Caloca, María J. ; Bustelo, Xosé R.; Simas, J. Pedro
Fecha de publicación : jun-2006
Editor: American Society for Microbiology
Citación : Journal of Virology 80(12): 6123–6135 (2006)
Resumen: Gammaherpesviruses subvert eukaryotic signaling pathways to favor latent infections in their cellular reservoirs. To this end, they express proteins that regulate or replace functionally specific signaling proteins of eukaryotic cells. Here we describe a new type of such viral-host interaction that is established through M2, a protein encoded by murine gammaherpesvirus 68. M2 associates with Vav proteins, a family of phosphorylation-dependent Rho/Rac exchange factors that play critical roles in lymphocyte signaling. M2 expression leads to Vav1 hyperphosphorylation and to the subsequent stimulation of its exchange activity towards Rac1, a process mediated by the formation of a trimolecular complex with Src kinases. This heteromolecular complex is coordinated by proline-rich and Src family-dependent phosphorylated regions of M2. Infection of Vav-deficient mice with gammaherpesvirus 68 results in increased long-term levels of latency in germinal center B lymphocytes, corroborating the importance of the M2/Vav cross talk in the process of viral latency. These results reveal a novel strategy used by the murine gammaherpesvirus family to subvert the lymphocyte signaling machinery to its own benefit.
Versión del editor: http://dx.doi.org/10.1128/JVI.02700-05
URI : http://hdl.handle.net/10261/5129
DOI: 10.1128/JVI.02700-05
ISSN: 0022-538X
Aparece en las colecciones: (IBMCC) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 



NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.