English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/51244
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

A developmentally regulated two-step process generates a noncentrosomal microtubule network in Drosophila tracheal cells

AutorBrodu, Véronique; Baffet, Alexandre D.; Droguen, Pierre-Marie le; Casanova, Jordi ; Guichet, Antoine
Fecha de publicación2010
CitaciónDevelopmental Cell 18: 790-801 (2010)
ResumenMicrotubules (MTs) are essential for many cell features, such as polarity, motility, shape, and vesicle trafficking. Therefore, in a multicellular organism, their organization differs between cell types and during development; however, the control of this process remains elusive. Here, we show that during Drosophila tracheal morphogenesis, MT reorganization is coupled to relocalization of the microtubule organizing centers (MTOC) components from the centrosome to the apical cell domain from where MTs then grow. We reveal that this process is controlled by the trachealess patterning gene in a two-step mechanism. MTOC components are first released from the centrosome by the activity of the MT-severing protein Spastin, and then anchored apically through the transmembrane protein Piopio. We further show that these changes are essential for tracheal development, thus stressing the functional relevance of MT reorganization for morphogenesis. © 2010 Elsevier Inc.
Identificadoresdoi: 10.1016/j.devcel.2010.03.015
issn: 1534-5807
e-issn: 1878-1551
Aparece en las colecciones: (IBMB) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Mostrar el registro completo

Artículos relacionados:

NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.