English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/51159
Título

Calcium dynamics in the secretory granules of neuroendocrine cells

AutorÁlvarez, Javier
Fecha de publicación2012
EditorElsevier
CitaciónCell Calcium 51(3-4): 331-337 (2012)
ResumenCellular Ca 2+signaling results from a complex interplay among a variety of Ca 2+ fluxes going across the plasma membrane and across the membranes of several organelles, together with the buffering effect of large numbers of Ca 2+-binding sites distributed along the cell architecture. Endoplasmic and sarcoplasmic reticulum, mitochondria and even nucleus have all been involved in cellular Ca 2+ signaling, and the mechanisms for Ca 2+ uptake and release from these organelles are well known. In neuroendocrine cells, the secretory granules also constitute a very important Ca 2+-storing organelle, and the possible role of the stored Ca 2+ as a trigger for secretion has attracted considerable attention. However, this possibility is frequently overlooked, and the main reason for that is that there is still considerable uncertainty on the main questions related with granular Ca 2+ dynamics, e.g., the free granular [Ca 2+], the physical state of the stored Ca 2+ or the mechanisms for Ca 2+ accumulation and release from the granules. This review will give a critical overview of the present state of knowledge and the main conflicting points on secretory granule Ca 2+ homeostasis in neuroendocrine cells. © 2011 Elsevier Ltd.
URIhttp://hdl.handle.net/10261/51159
DOI10.1016/j.ceca.2011.12.002
Identificadoresdoi: 10.1016/j.ceca.2011.12.002
issn: 0143-4160
e-issn: 1532-1991
Aparece en las colecciones: (IBGM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.