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Apoptotic cells enhance IL-10 and reduce IL-23 production in human dendritic cells treated with zymosan

AutorMunicio, Cristina ; Hugo, Etzel; Alvarez, Yolanda ; Alonso, Sara ; Blanco, Lydia; Fernández, Nieves ; Sánchez Crespo, Mariano
Fecha de publicación2011
CitaciónMolecular Immunology 49: 97-106 (2011)
ResumenContact of apoptotic cells (AC) with phagocytes tilts the balance of pro-inflammatory and anti-inflammatory cytokines. To address the cell- and stimulus-dependency of this mechanism, human monocyte-derived dendritic cells were treated with Jurkat AC in the presence and absence of different stimuli. AC reduced the production of IL-23 and enhanced the production of IL-10 elicited by zymosan, but they did not influence IL-12 p70 production nor did they modify the effect of LPS. Since formation of lipid bodies (LB) and PGE2 production have been associated with IL-10 induction, the effect of PGE2, the formation of LB, and the role of PPAR-γ were assessed. Exogenous PGE2 enhanced IL-10 expression, but no evidence of PGE2 production elicited by AC was obtained. Inhibition of PPAR-γ activity reduced the production of IL-10 both in the presence and in the absence of AC, but formation of LB in response to zymosan and AC was not observed. Notably, AC induced a transient nuclear translocation of both the CREB coactivator CRTC2/TORC2 and the homeodomain protein PBX1, which are involved in the CREB/HOX/PBX/MEIS transcription complex. These data show a selective effect of AC on the production of cytokines elicited by the fungal surrogate zymosan through the enhancement of CREB-dependent transcription. © 2011 Elsevier Ltd.
Identificadoresdoi: 10.1016/j.molimm.2011.07.022
issn: 0161-5890
e-issn: 1872-9142
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