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Specific GATA factors act as conserved inducers of an endodermal-EMT

AuthorsCampbell, Kyra; Whissell, Gavin; Franch-Marro, Xavier ; Batlle, Eduard; Casanova, Jordi
Issue Date2011
CitationDevelopmental Cell 21(6): 1051-1061 (2011)
AbstractThe epithelial-to-mesenchymal transition (EMT) converts cells from static epithelial to migratory mesenchymal states (Hay, 1995). Here, we demonstrate that EMT in the Drosophila endoderm is dependent on the GATA-factor Serpent (Srp), and that Srp acts as a potent trigger for this transition when activated ectopically. We show that Srp affects endodermal-EMT through a downregulation of junctional dE-Cadherin (dE-Cad) protein, without a block in its transcription. Moreover, the relocalization of dE-Cad is achieved through the direct repression of crumbs (crb) by Srp. Finally, we show that hGATA-6, an ortholog of Srp, induces a similar transition in mammalian cells. Similar to Srp, hGATA-6 acts through the downregulation of junctional E-Cad, without blocking its transcription, and induces the repression of a Crumbs ortholog, crb2. Together, these results identify a set of GATA factors as a conserved alternative trigger to repress epithelial characteristics and confer migratory capabilities on epithelial cells in development and pathogenesis. © 2011 Elsevier Inc.
Identifiersdoi: 10.1016/j.devcel.2011.10.005
issn: 1534-5807
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