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Title: | SOS-Independent Induction of dinB Transcription by β-Lactam-Mediated Inhibition of Cell Wall Synthesis in Escherichia coli |
Authors: | Pérez-Capilla, Tatiana; Baquero, María del Rosario; Gómez-Gómez, José María; Ionel, Alina; Martín, Soledad; Blázquez, Jesús |
Issue Date: | Feb-2005 |
Publisher: | American Society for Microbiology |
Citation: | Journal of Bacteriology 187(4): 1515–1518 (2005) |
Abstract: | Transcription of the dinB gene, encoding DNA polymerase IV, is induced by the inhibition of cell wall synthesis at different levels. Using the β-lactam antibiotic ceftazidime, a PBP3 inhibitor, as a model, we have shown that this induction is independent of the LexA/RecA regulatory system. Induction of dinB transcription mediated by ceftazidime produces an increase in the reversion of a +1 Lac frameshift mutation. |
Publisher version (URL): | http://dx.doi.org/10.1128/JB.187.4.1515-1518.2005 |
URI: | http://hdl.handle.net/10261/5097 |
DOI: | http://dx.doi.org/10.1128/JB.187.4.1515-1518.2005 |
ISSN: | 1098-5530 |
Appears in Collections: | (CAB) Artículos (CNB) Artículos |
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