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SOS-Independent Induction of dinB Transcription by β-Lactam-Mediated Inhibition of Cell Wall Synthesis in Escherichia coli

AuthorsPérez-Capilla, Tatiana; Baquero, María del Rosario; Gómez-Gómez, José María; Ionel, Alina; Martín, Soledad; Blázquez, Jesús
Issue DateFeb-2005
PublisherAmerican Society for Microbiology
CitationJournal of Bacteriology 187(4): 1515–1518 (2005)
AbstractTranscription of the dinB gene, encoding DNA polymerase IV, is induced by the inhibition of cell wall synthesis at different levels. Using the β-lactam antibiotic ceftazidime, a PBP3 inhibitor, as a model, we have shown that this induction is independent of the LexA/RecA regulatory system. Induction of dinB transcription mediated by ceftazidime produces an increase in the reversion of a +1 Lac frameshift mutation.
Publisher version (URL)http://dx.doi.org/10.1128/JB.187.4.1515-1518.2005
Appears in Collections:(CAB) Artículos
(CNB) Artículos
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