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Título

Differential inhibition of cellular and Sindbis virus translation by brefeldin A

AutorMolina, Susana; Sanz, Miguel Ángel ; Madan, Vanesa; Ventoso, Iván ; Castelló, Alfredo; Carrasco Llamas, Luis
Palabras claveBrefeldin A
Sindbis virus
Cellular translation
Viral protein synthesis
Sindbis virus replication
Fecha de publicación23-mar-2007
EditorElsevier
CitaciónVirology, Vol. 363, Issue 2, 5 July 2007, Pages 430-436
ResumenBrefeldin A is a macrolide compound that interferes with the secretory pathway and also affects protein synthesis in mammalian cells. As a result, this antibiotic impedes the maturation of viral glycoproteins of enveloped viruses and viral genome replication in several virus species. In the present work, we show that translation of subgenomic mRNA from Sindbis virus, which in contrast to cellular translation is resistant to brefeldin A after prolonged treatment. The phosphorylation of eIF2 as a result of brefeldin A treatment correlates with the inhibition of cellular translation, while late viral protein synthesis is resistant to this phosphorylation. The effect of brefeldin A on Sindbis virus replication was also examined using a Sindbis virus replicon. Although brefeldin A delayed viral RNA synthesis, translation by non-replicative viral RNAs was not affected, reinforcing the idea that brefeldin A delays viral RNA replication, but does not directly affect Sindbis virus protein synthesis
Versión del editorhttp://dx.doi.org/10.1016/j.virol.2007.02.001
URIhttp://hdl.handle.net/10261/5048
DOI10.1016/j.virol.2007.02.001
ISSN0042-6822 (Print)
1096-0341 (Online)
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