English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/50288
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorGaleano, Eva-
dc.contributor.authorNieto, Elena-
dc.contributor.authorGarcía-Pérez, Ana Isabel-
dc.contributor.authorDelgado, M. Dolores-
dc.contributor.authorPinilla, Montserrat-
dc.contributor.authorSancho, Pilar-
dc.date.accessioned2012-05-29T07:26:53Z-
dc.date.available2012-05-29T07:26:53Z-
dc.date.issued2005-
dc.identifierdoi: 10.1016/j.leukres.2005.03.014-
dc.identifierissn: 0145-2126-
dc.identifier.citationLeukemia Research 29(10): 1201-1211 (2005)-
dc.identifier.urihttp://hdl.handle.net/10261/50288-
dc.description.abstractDequalinium (DQA) is a delocalized lipophylic cation that selectively targets the mitochondria of carcinoma cells. However, the underlying mechanisms of DQA action are not yet well understood. We have studied the effects of DQA on two different leukemia cell lines: NB4, derived from acute promyelocytic leukemia, and K562, derived from chronic myeloid leukemia. We found that DQA displays differential cytotoxic activity in these cell lines. In NB4 cells, a low DQA concentration (2 μM) induces a mixture of apoptosis and necrosis, whereas a high DQA concentration (20 μM) induces mainly necrosis. However, K562 cell death was always by necrosis as the cells showed a resistance to apoptosis at all time-periods and DQA concentrations assayed. In both cell lines, the cell death seems to be mediated by alterations of mitochondrial function as evidenced by loss of mitochondrial transmembrane potential, O 2 - accumulation and ATP depletion. The current study improves the knowledge on DQA as a novel anticancer agent with a potential application in human acute promyelocytic leukemia chemotherapy. © 2005 Elsevier Ltd. All rights reserved.-
dc.description.sponsorshipThis work was supported by the Comunidad Autónoma de Madrid (CAM) and Fondo de Investigaciones Sanitarias (FIS).-
dc.language.isoeng-
dc.publisherElsevier-
dc.rightsclosedAccess-
dc.titleEffects of the antitumoural dequalinium on NB4 and K562 human leukemia cell lines: Mitochondrial implication in cell death-
dc.typeartículo-
dc.identifier.doi10.1016/j.leukres.2005.03.014-
dc.date.updated2012-05-29T07:26:53Z-
dc.description.versionPeer Reviewed-
Appears in Collections:(IBBTEC) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show simple item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.