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PU.1 expression is restored upon treatment of chronic myeloid leukemia patients

AuthorsAlbajar, Marta ; Gutiérrez, Pilar; Richard, C.; Rosa-Garrido, Manuel ; Gómez-Casares, M. Teresa; Steegmann, Juan L.; León, Javier ; Delgado, M. Dolores
Issue Date2008
CitationCancer Letters 270(2): 328-336 (2008)
AbstractThe PU.1 transcription factor is a crucial regulator of hematopoiesis which expression is altered in various leukemic processes. Our previous work in chronic myeloid leukemia (CML) cells demonstrated that interferon-α upregulated PU.1 expression. Here we show that expression of PU.1 is severely impaired in patients with CML at diagnosis. However, the PU.1 suppression is abrogated in patients in remission, after interferon-α or imatinib treatment. These effects are not found in patients with other myeloproliferative diseases such as polycythemia vera or essential thrombocythemia. PU.1 could, therefore, be used as an additional marker of the response to the treatment of the CML. © 2008 Elsevier Ireland Ltd. All rights reserved.
DescriptionEl pdf del artículo es el manuscrito de autor.
Publisher version (URL)http://dx.doi.org/10.1016/j.canlet.2008.05.024
Identifiersdoi: 10.1016/j.canlet.2008.05.024
issn: 0304-3835
Appears in Collections:(IBBTEC) Artículos
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