English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/50203
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

PU.1 expression is restored upon treatment of chronic myeloid leukemia patients

AuthorsAlbajar, Marta ; Gutiérrez, Pilar; Richard, C.; Rosa-Garrido, Manuel ; Gómez-Casares, M. Teresa; Steegmann, Juan L.; León, Javier ; Delgado, M. Dolores
Issue Date2008
PublisherElsevier
CitationCancer Letters 270(2): 328-336 (2008)
AbstractThe PU.1 transcription factor is a crucial regulator of hematopoiesis which expression is altered in various leukemic processes. Our previous work in chronic myeloid leukemia (CML) cells demonstrated that interferon-α upregulated PU.1 expression. Here we show that expression of PU.1 is severely impaired in patients with CML at diagnosis. However, the PU.1 suppression is abrogated in patients in remission, after interferon-α or imatinib treatment. These effects are not found in patients with other myeloproliferative diseases such as polycythemia vera or essential thrombocythemia. PU.1 could, therefore, be used as an additional marker of the response to the treatment of the CML. © 2008 Elsevier Ireland Ltd. All rights reserved.
DescriptionEl pdf del artículo es el manuscrito de autor.
Publisher version (URL)http://dx.doi.org/10.1016/j.canlet.2008.05.024
URIhttp://hdl.handle.net/10261/50203
DOI10.1016/j.canlet.2008.05.024
Identifiersdoi: 10.1016/j.canlet.2008.05.024
issn: 0304-3835
Appears in Collections:(IBBTEC) Artículos
Files in This Item:
File Description SizeFormat 
PU.1.pdf302,43 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.