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dc.contributor.authorNavascués, Joaquín-
dc.contributor.authorBengoechea, Rocío-
dc.contributor.authorTapia, Olga-
dc.contributor.authorCasafont, Íñigo-
dc.contributor.authorBerciano, María T.-
dc.contributor.authorLafarga, Miguel-
dc.identifierdoi: 10.1016/j.jsb.2008.04.013-
dc.identifierissn: 1047-8477-
dc.identifier.citationJournal of Structural Biology 163: 137-146 (2008)-
dc.description.abstractCajal bodies (CBs) are nuclear organelles involved in the maturation of small nuclear ribonucleoproteins required for the processing of pre-mRNAs. They concentrate coilin, splicing factors and the survival of motor neuron protein (SMN). By using immunocytochemistry and transfection experiments with GFP-SUMO-1, DsRed1-Ubc9, GFP-coilin and GFP-SMN constructs we demonstrate the presence of SUMO-1 and the SUMO conjugating enzyme (Ubc9) in a subset of CBs in undifferentiated neuron-like UR61 cells. Furthermore, SUMO-1 is transiently localized into neuronal CBs from adult nervous tissue in response to osmotic stress or inhibition of methyltransferase activity. SUMO-1-positive CBs contain coilin, SMN and small nuclear ribonucleoproteins, suggesting that they are functional CBs involved in pre-mRNA processing. Since coilin and SMN have several putative motifs of SUMO-1 modification, we suggest that the sumoylation of coilin and/or SMN might play a role in the molecular reorganization of CBs during the neuronal differentiation or stress-response. © 2008 Elsevier Inc. All rights reserved.-
dc.description.sponsorshipThis work was supported by the following grants: “Dirección General de Investigacion” of Spain (BFU2005-01030), and Centro de Investigación Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED; CB06/05/0037) from Spain.-
dc.titleSUMO-1 transiently localizes to Cajal bodies in mammalian neurons-
dc.description.versionPeer Reviewed-
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