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Tissue-specific requirements for FGF8 during early inner ear development

AuthorsDomínguez-Frutos, Elena; Vendrell, Victor; Alvarez, Yolanda CSIC ORCID; Zelarayan, Laura Cecilia; López-Hernández, Iris; Ros, María A. CSIC ORCID; Schimmang, Thomas CSIC ORCID
Issue Date2009
CitationMechanisms of Development 126(10): 873-881 (2009)
AbstractSeveral members of the FGF gene family have been shown to intervene from various tissue sources to direct otic placode induction and otic vesicle formation. In this study we define the roles of FGF8, found in different expression domains during this process, in mice and chickens. By conditional inactivation of Fgf8 in distinct tissue compartments we demonstrate that Fgf8 is required in the mesoderm and endoderm during early inner ear development. In the chicken embryo, overexpression of Fgf8 from various tissue sources during otic specification leads to a loss of otic tissue. In contrast ectopic overexpression of Fgf10, a major player during murine otic induction, does not influence otic vesicle formation in chicken embryos but results in the formation of ectopic structures with a non-otic character. This study underlines the crucial role of a defined Fgf8 expression pattern controlling inner ear formation in vertebrates. © 2009 Elsevier Ireland Ltd. All rights reserved.
DescriptionEl pdf del artículo es el manuscrito de autor.
Publisher version (URL)http://dx.doi.org/10.1016/j.mod.2009.07.004
Identifiersdoi: 10.1016/j.mod.2009.07.004
issn: 0925-4773
Appears in Collections:(IBBTEC) Artículos
(IBGM) Artículos
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