English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/50091
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Long-term treatment with fluoxetine induces desensitization of 5-HT 4 receptor-dependent signalling and functionality in rat brain

AuthorsVidal, Rebeca CSIC ORCID; Valdizán, Elsa M. CSIC ORCID; Mostany, Ricardo; Pazos, Ángel CSIC ORCID; Castro, Elena CSIC ORCID
Issue Date2009
PublisherJohn Wiley & Sons
CitationJournal of Neurochemistry 110(3): 1120-1127 (2009)
AbstractThe mode of action of antidepressant drugs may be related to mechanisms of monoamines receptor adaptation, including serotonin 5-HT4 receptor subtypes. Here we investigated the effects of repeated treatment with the selective serotonin reuptake inhibitor fluoxetine for 21 days (5 and 10 mg/kg, p.o., once daily) on the sensitivity of 5-HT4 receptors by using receptor autoradiography, adenylate cyclase assays and extracellular recording techniques in rat brain. Fluoxetine treatment decreased the density of 5-HT 4 receptor binding in the CA1 field of hippocampus as well as in several areas of the striatum over the doses of 5-10 mg/kg. In a similar way, we found a significant lower response to zacopride-stimulated adenylate cyclase activity in the fluoxetine 10 mg/kg/day treated group. Furthermore, post-synaptic 5-HT4 receptor activity in hippocampus-measured as the excitatory action of zacopride in the pyramidal cells of CA1 evoked by Schaffer collateral stimulation was attenuated in rats treated with both doses of fluoxetine. Taken together, these results support the concept that a net decrease in the signalization pathway of 5-HT4 receptors occurs after chronic selective serotonin reuptake inhibitor treatment: this effect may underlie the therapeutic efficacy of these drugs. © 2009 International Society for Neurochemistry.
DescriptionEl pdf del artículo es la versión pre-print.
Publisher version (URL)http://dx.doi.org/10.1111/j.1471-4159.2009.06210.x
URIhttp://hdl.handle.net/10261/50091
DOIhttp://dx.doi.org/10.1111/j.1471-4159.2009.06210.x
Identifiersissn: 0022-3042
Appears in Collections:(IBBTEC) Artículos
Files in This Item:
File Description SizeFormat 
Long term treatment.pdf153,31 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.