Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/50051
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Título

Fish melanocortin system

AutorCerdá-Reverter, José Miguel CSIC ORCID CVN ; Agulleiro Gozalbo, Maria Josep CSIC ORCID; Guillot, Raúl CSIC ORCID; Sánchez Martínez, Elisa CSIC ORCID ; Ceinos, Rosa M. CSIC; Rotllant, Josep CSIC ORCID
Palabras claveMelanocortin-stimulating hormone (MSH)
Proopiomelanocortin
Agouti-signalling protein
Agouti-related protein (AGRP)
Melanocortin receptors
Melanocortin receptor accessory protein (MRAP)
Food intake
Pigmentation
Stress
Fecha de publicación11-jun-2011
EditorElsevier
CitaciónEuropean Journal of Pharmacology 660(1): 53-60 (2011)
ResumenMelanocortin signalling is mediated by binding to a family of G protein-coupled receptors that positively couple to adenylyl cyclase. Tetrapod species have five melanocortin (MC1-MC5) receptors. The number of receptors varies in fish, zebrafish, for example, having six melanocortin receptors, with two copies of the melanocortin MC5 receptor, while pufferfish have 4 receptors with no melanocortin MC3 receptor and one copy of melanocortin MC5 receptor. Fish genomes also exhibit orthologue genes for agouti-signalling protein (ASP) and -related protein (AGRP). AGRP expression is confined to a small area in the hypothalamus but ASP is expressed in the skin. Fish melanocortin MC2 receptor is specific for ACTH and requires the cooperation of accessory proteins (MRAP) to reach functional expression. The four other melanocortin MC receptors distinctively bind MSHs. The interaction of α-MSH and melanocortin MC 1 receptor plays a key point in the control of the pigmentation and mutations of melanocortin MC1 receptor are responsible for reduced melanization. Both melanocortin MC4 and MC5 receptor are expressed in the hypothalamus, and central melanocortin MC4 receptor expression is thought to regulate the energy balance through the modulation of feeding behaviour. In addition, the peripheral melanocortin system also regulates lipid metabolism by acting at hepatic melanocortin MC2 and MC5 receptors. Both sea bass melanocortin MC1 and MC 4 receptors are constitutively expressed in vitro and both ASP and AGRP work as inverse agonists but only after inhibition of the phosphodiesterase system. Accordingly, the overexpression of AGRP and ASP transgenes promotes obesity and reduces melanization in zebrafish, respectively.
Descripción31 p. Review
Versión del editorhttp://dx.doi.org/10.1016/j.ejphar.2010.10.108
URIhttp://hdl.handle.net/10261/50051
DOI10.1016/j.ejphar.2010.10.108
ISSN0014-2999
E-ISSN1879-0712
Aparece en las colecciones: (IATS) Artículos
(IIM) Artículos




Ficheros en este ítem:
Fichero Descripción Tamaño Formato
Fish melanocortin system.pdf140,26 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo

CORE Recommender

SCOPUSTM   
Citations

94
checked on 20-mar-2024

WEB OF SCIENCETM
Citations

89
checked on 16-feb-2024

Page view(s)

364
checked on 29-mar-2024

Download(s)

795
checked on 29-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.