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dc.contributor.authorCerdá-Reverter, José Miguel-
dc.contributor.authorAgulleiro Gozalbo, Maria Josep-
dc.contributor.authorGuillot, Raúl-
dc.contributor.authorSánchez, Elisa-
dc.contributor.authorCeinos, Rosa M.-
dc.contributor.authorRotllant, Josep-
dc.date.accessioned2012-05-24T09:51:48Z-
dc.date.available2012-05-24T09:51:48Z-
dc.date.issued2011-06-11-
dc.identifier.citationEuropean Journal of Pharmacology 660(1): 53-60 (2011)es_ES
dc.identifier.issn0014-2999-
dc.identifier.urihttp://hdl.handle.net/10261/50051-
dc.description31 p. Reviewes_ES
dc.description.abstractMelanocortin signalling is mediated by binding to a family of G protein-coupled receptors that positively couple to adenylyl cyclase. Tetrapod species have five melanocortin (MC1-MC5) receptors. The number of receptors varies in fish, zebrafish, for example, having six melanocortin receptors, with two copies of the melanocortin MC5 receptor, while pufferfish have 4 receptors with no melanocortin MC3 receptor and one copy of melanocortin MC5 receptor. Fish genomes also exhibit orthologue genes for agouti-signalling protein (ASP) and -related protein (AGRP). AGRP expression is confined to a small area in the hypothalamus but ASP is expressed in the skin. Fish melanocortin MC2 receptor is specific for ACTH and requires the cooperation of accessory proteins (MRAP) to reach functional expression. The four other melanocortin MC receptors distinctively bind MSHs. The interaction of α-MSH and melanocortin MC 1 receptor plays a key point in the control of the pigmentation and mutations of melanocortin MC1 receptor are responsible for reduced melanization. Both melanocortin MC4 and MC5 receptor are expressed in the hypothalamus, and central melanocortin MC4 receptor expression is thought to regulate the energy balance through the modulation of feeding behaviour. In addition, the peripheral melanocortin system also regulates lipid metabolism by acting at hepatic melanocortin MC2 and MC5 receptors. Both sea bass melanocortin MC1 and MC 4 receptors are constitutively expressed in vitro and both ASP and AGRP work as inverse agonists but only after inhibition of the phosphodiesterase system. Accordingly, the overexpression of AGRP and ASP transgenes promotes obesity and reduces melanization in zebrafish, respectively.es_ES
dc.description.sponsorshipThis work was partially supported by grants from the Ministry of Science and Innovation (MICINN) AGL2007-65744-C03-02, CSD 2007-00002 and AGL2010-22247-C03-01 to JM C-R. MJA is recipient of a “Juan de la Cierva” research contract (2009) from the Spanish Science and Innovation Ministry.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsopenAccesses_ES
dc.subjectMelanocortin-stimulating hormone (MSH)es_ES
dc.subjectProopiomelanocortin (POMC)es_ES
dc.subjectAgoutisignalling protein (ASIP)es_ES
dc.subjectAgouti-related protein (AGRP)es_ES
dc.subjectMelanocortin Receptores_ES
dc.subjectMelanocortin receptor accessory protein (MRAP)es_ES
dc.subjectFood Intakees_ES
dc.subjectPigmentationes_ES
dc.subjectStresses_ES
dc.titleFish melanocortin systemes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.ejphar.2010.10.108-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.ejphar.2010.10.108es_ES
dc.identifier.e-issn1879-0712-
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