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| Título: | α2-adrenoceptor functionality in postmortem frontal cortex of depressed suicide victims |
Autor: | Valdizán, Elsa M. CSIC ORCID; Diez-Alarcia, Rebeca; Pilar-Cuéllar, Fuencisla CSIC ORCID; Pazos, Ángel CSIC ORCID | Palabras clave: | Adenylyl cyclase α2-adrenoceptor |
Fecha de publicación: | nov-2010 | Editor: | Elsevier | Citación: | Biological Psychiatry 68(9): 869-872 (2010) | Resumen: | [Background]: Alterations in brain density and signaling associated with monoamine receptors are believed to play a role in depressive disorders. This study evaluates the functional status of α2A-adrenoceptors in postmortem frontal cortex of depressed subjects. [Methods]: G-protein activation and inhibition of adenylyl cyclase (AC) activity induced by the α2-adrenoceptor agonist UK14304 were measured in triplicate in samples from 15 suicide victims with an antemortem diagnosis of major depression and 15 matched control subjects. [Results]: Basal [35S] guanosine γ thio-phosphate (GTPγS) binding and cyclic adenosine monophosphate accumulation did not differ between groups. In depressed victims, an increase in [35S] GTPγS binding potency (EC50 = .58 μmol/L vs. EC50 = 3.31 μmol/L; p < .01; depressed vs. control) and a significant reduction in the maximal inhibition of AC activity (Imax = 27 ± 4% vs. Imax = 47 ± 5%; p < .01) were observed after incubation with the α2-adrenoceptor agonist UK14304. No differences were found between antidepressant-free and antidepressant-treated subjects. A significant relationship between EC50 values for [35S] GTPγS and Imax values for AC assay was found (n=30; r=−.43; p<.05). [Conclusions]: The dual regulation of α2A-adrenoceptor signaling pathways raises the possibility that factors affecting the G-protein cycle and/or selective access of Gαi/o–protein to AC might be relevant to receptor abnormalities in depression, providing further support for the involvement of α2A-adrenoceptors in the pathogenesis of depression. | Descripción: | El pdf del artículo es el manuscrito de autor.-- et al. | Versión del editor: | http://dx.doi.org/10.1016/j.biopsych.2010.07.023 | URI: | http://hdl.handle.net/10261/49806 | DOI: | 10.1016/j.biopsych.2010.07.023 | ISSN: | 0006-3223 |
| Aparece en las colecciones: | (IBBTEC) Artículos |
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| a2-adrenoceptor.pdf | 763,15 kB | Adobe PDF |  Visualizar/Abrir |
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