English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/49743
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Cell proliferation inhibitory and apoptosis-inducing properties of anacardic acid and lunasin in human breast cancer MDA-MB-231 cells

AuthorsHsieh, Chia-Chien; Hernández-Ledesma, Blanca ; Lumen, Ben O. de
KeywordsAnacardic acid
Lunasin
Breast cancer cells
Cell proliferation
Apoptosis
Signal transduction genes
Issue DateMar-2011
PublisherElsevier
CitationFood Chemistry 125(2): 630-636 (2011)
AbstractThe combination of two or more chemopreventive agents is currently being used to achieve greater inhibitory effects on breast cancer cells. Anacardic acid and lunasin are two plant-derived compounds that have been associated with anti-carcinogenic properties. These compounds show inhibitory effects on cell proliferation and inducing properties of apoptosis in human breast cancer MDA-MB-231 cell line. Both lunasin and anacardic acid exert their effects through the modulation of expression of several genes involved in cell cycle, apoptosis and signal transduction. Their combination arrests the cell cycle in S-phase and induces apoptosis at higher levels than that observed when each compound is used individually. This combination also promotes the inhibition of ERBB2, AKT1, JUN and RAF1 signalling gene expression, whose up-regulation has been reported as responsible for breast cancer cells growth and resistance to apoptosis. Our results introduce these two compounds as a promising strategy to prevent/treat breast cancer.
Description7 páginas, 4 figuras, 1 tabla.
Publisher version (URL)http://dx.doi.org/10.1016/j.foodchem.2010.09.051
URIhttp://hdl.handle.net/10261/49743
DOI10.1016/j.foodchem.2010.09.051
ISSN0308-8146
Appears in Collections:(CIAL) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.