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Title

Different steps of sexual development are differentially regulated by the Sec8p and Exo70p exocyst subunits

AuthorsSharifmoghadam, M. R. ; León, Nagore de ; Hoya, Marta ; Curto, María Ángeles ; Valdivieso, María Henar
KeywordsYeast
Sexual development
Mating
Sporulation
Exocyst
Protein trafficking
Issue DateApr-2010
PublisherBlackwell Publishing
CitationFEMS Microbiology Letters 305(1): 71-80 (2010)
AbstractIn this paper we show that in Schizosaccharomyces pombe, mating-specific cell adhesion is dependent on the exocyst subunit Sec8p, but independent of the exocyst subunit Exo70p. In the absence of Exo70p, the forespore membrane does not develop properly and the leading edge protein Meu14p is abnormally distributed. Additionally, the spindle pole body is aberrant in a significant number of exo70Δ asci. In both the sec8-1 and the exo70Δ mutants, the development of the spore cell wall is impaired. These results show that different steps of sexual development are differentially regulated by the exocyst and suggest the existence of exocyst subcomplexes with distinct roles in mating.
Description10 páginas, 5 figuras.-- El pdf del artículo es la versión pre-print.
Publisher version (URL)http://dx.doi.org/10.1111/j.1574-6968.2010.01915.x
URIhttp://hdl.handle.net/10261/49576
DOI10.1111/j.1574-6968.2010.01915.x
ISSN0378-1097
E-ISSN1574-6968
Appears in Collections:(IBFG) Artículos
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