English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/49572
Título

The emerging role of TGF-β superfamily coreceptors in cancer

AutorBernabéu, Carmelo ; López-Novoa, José M.; Quintanilla, Miguel
Palabras claveTransforming growth factor-beta receptor
Cancer
Endoglin
Betaglycan
Angiogenesis
Fecha de publicaciónoct-2009
EditorElsevier
CitaciónBBA - Biochimica et Biophysica Acta 1792(10): 954-973 (2009)
ResumenThe transforming growth factor beta (TGF-beta) signaling pathway plays a key role in different physiological processes such as development, cellular proliferation, extracellular matrix synthesis, angiogenesis or immune responses and its deregulation may result in tumor development. The TGF-beta coreceptors endoglin and betaglycan are emerging as modulators of the TGF-beta response with important roles in cancer. Endoglin is highly expressed in the tumor-associated vascular endothelium with prognostic significance in selected neoplasias and with potential to be a prime vascular target for antiangiogenic cancer therapy. On the other hand, the expression of endoglin and betaglycan in tumor cells themselves appears to play an important role in the progression of cancer, influencing cell proliferation, motility, invasiveness and tumorigenicity. In addition, experiments in vitro and in vivo in which endoglin or betaglycan expression is modulated have provided evidence that they act as tumor suppressors. The purpose of this review was to highlight the potential of membrane and soluble forms of the endoglin and betaglycan proteins as molecular targets in cancer diagnosis and therapy
Descripción20 páginas, 6 figuras, 2 tablas.
Versión del editorhttp://dx.doi.org/10.1016/j.bbadis.2009.07.003
URIhttp://hdl.handle.net/10261/49572
DOI10.1016/j.bbadis.2009.07.003
ISSN0006-3002
Aparece en las colecciones: (CIB) Artículos
(IIBM) Artículos
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.