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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | González-Aguilera, Cristina | - |
dc.contributor.author | Tous, Cristina | - |
dc.contributor.author | Gómez-González, Belén | - |
dc.contributor.author | Huertas Sánchez, Pablo | - |
dc.contributor.author | Luna, Rosa | - |
dc.contributor.author | Aguilera, Andrés | - |
dc.date.accessioned | 2012-05-10T06:42:20Z | - |
dc.date.available | 2012-05-10T06:42:20Z | - |
dc.date.issued | 2008-10-01 | - |
dc.identifier.citation | Molecular Biology of the Cell 19(10): 4310-4318 (2008) | es_ES |
dc.identifier.issn | 1059-1524 | - |
dc.identifier.other | PMID: 18667528 | - |
dc.identifier.other | PMC2555943 | - |
dc.identifier.uri | http://hdl.handle.net/10261/49485 | - |
dc.description | 9 páginas, 7 figuras. Monitoring editor: Marvin P. Wickens. | es_ES |
dc.description.abstract | The eukaryotic THO/TREX complex, involved in mRNP biogenesis, plays a key role in the maintenance of genome integrity in yeast. mRNA export factors such as Thp1-Sac3 also affect genome integrity, but their mutations have other phenotypes different from those of THO/TREX. Sus1 is a novel component of SAGA transcription factor that also associates with Thp1-Sac3, but little is known about its effect on genome instability and transcription. Here we show that Thp1, Sac3, and Sus1 form a functional unit with a role in mRNP biogenesis and maintenance of genome integrity that is independent of SAGA. Importantly, the effects of ribozyme-containing transcription units, RNase H, and the action of human activation-induced cytidine deaminase on transcription and genome instability are consistent with the possibility that R-loops are formed in Thp1-Sac3-Sus1-Cdc31 as in THO mutants. Our data reveal that Thp1-Sac3-Sus1-Cdc31, together with THO/TREX, define a specific pathway connecting transcription elongation with export via an RNA-dependent dynamic process that provides a feedback mechanism for the control of transcription and the preservation of genetic integrity of transcribed DNA regions. | es_ES |
dc.description.sponsorship | This work was supported by grants from the Spanish Ministry of Science and Education (SAF2003-00204 and BFU2006-05260) and Junta de Andalucía (CVI102 and CVI624). C.G.-A. and B.G.-G. were the recipients of (Formación Profesorado Universitario) Ph.D. training grants from the Spanish Ministry of Science and Education. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Society for Cell Biology | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | CDC31 protein | es_ES |
dc.subject | Calcium-binding proteins | es_ES |
dc.subject | Cell cycle proteins | es_ES |
dc.subject | Nuclear proteins | es_ES |
dc.subject | Nucleocytoplasmic transport proteins | es_ES |
dc.subject | Porins | es_ES |
dc.subject | Activation induced cytidine deaminase (AICDA) | es_ES |
dc.subject | Cytidine deaminase | es_ES |
dc.subject | RNA | es_ES |
dc.title | The THP1-SAC3-SUS1-CDC31 Complex Works in Transcription Elongation-mRNA Export Preventing RNA-mediated Genome Instability | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1091/mbc.E08-04-0355 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1091/mbc.E08-04-0355 | es_ES |
dc.identifier.e-issn | 1939-4586 | - |
dc.identifier.pmid | 18667528 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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Genome_instability.pdf | 664,83 kB | Adobe PDF | Visualizar/Abrir |
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