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Título

p73 cooperates with Ras in the activation of MAP kinase signaling cascade

AutorVaqué, José P.; Fernández-Medarde, A.; León, Javier ; Marín, M. Carmen
Palabras clavep73
Ras
p53
ERK
p21
Differentiation
Fecha de publicación2007
EditorNature Publishing Group
CitaciónCell Death and Differentiation 14(2): 254–265 (2007)
ResumenThe p73 gene is capable of inducing cell cycle arrest, apoptosis, senescence, differentiation and to cooperate with oncogenic Ras in cellular transformation. Ras can be considered as a branch point in signal transduction, where diverse extracellular stimuli converge. The intensity of the mitogen-activated protein kinase (MAPK) cascade activation influences the cellular response to Ras. Despite the fundamental role of p53 in Ras-induced growth arrest and senescence, it remains unclear how the Ras/MEK/ERK pathway induces growth arrest in the absence of p53. We report here that oncogenic Ras stabilizes p73 resulting in p73 accumulation and enhancement of its activity. p73, in turn, induces a sustained activation of the MAP kinase cascade synergizing with oncogenic Ras. We also found that inhibition of p73 function modifies the cellular outcome to Ras activation inhibiting Ras-dependent differentiation. Here, we show for the first time that there is a signaling loop between Ras-dependent MAPK cascade activation and p73 function.
Versión del editorhttp://dx.doi.org/10.1038/sj.cdd.4401945
URIhttp://hdl.handle.net/10261/49403
DOI10.1038/sj.cdd.4401945
ISSN1350-9047
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