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dc.contributor.authorRuiz, Mario-
dc.contributor.authorSánchez, Diego-
dc.contributor.authorCanal, Inmaculada-
dc.contributor.authorAcebes-Vindel, José Ángel-
dc.contributor.authorGanfornina, M. D.-
dc.date.accessioned2012-05-08T11:35:24Z-
dc.date.available2012-05-08T11:35:24Z-
dc.date.issued2011-07-
dc.identifier.citationExperimental Gerontology 46(7): 579-589 (2011)es_ES
dc.identifier.issn0531-5565-
dc.identifier.urihttp://hdl.handle.net/10261/49375-
dc.description11 páginas, 7 figuras, 2 tablas.es_ES
dc.description.abstractApolipoprotein D (ApoD), a member of the Lipocalin family, is the gene most up-regulated with age in the mammalian brain. Its expression strongly correlates with aging-associated neurodegenerative and metabolic diseases. Two homologues of ApoD expressed in the Drosophila brain, Glial Lazarillo (GLaz) and Neural Lazarillo (NLaz), are known to alter longevity in male flies. However, sex differences in the aging process have not been explored so far for these genes. Here we demonstrate that NLaz alters lifespan in both sexes, but unexpectedly the lack of GLaz influences longevity in a sex-specific way, reducing longevity in males but not in females. While NLaz has metabolic functions similar to ApoD, the regulation of GLaz expression upon aging is the closest to ApoD in the aging brain. A multivariate analysis of physiological parameters relevant to lifespan modulation uncovers both common and specialized functions for the two Lipocalins, and reveals that changes in protein homeostasis account for the observed sex-specific patterns of longevity. The response to oxidative stress and accumulation of lipid peroxides are among their common functions, while the transcriptional and behavioral response to starvation, the pattern of daily locomotor activity, storage of fat along aging, fertility, and courtship behavior differentiate NLaz from GLaz mutants. We also demonstrate that food composition is an important environmental parameter influencing stress resistance and reproductive phenotypes of both Lipocalin mutants. Since ApoD shares many properties with the common ancestor of invertebrate Lipocalins, we must benefit from this global comparison with both GLaz and NLaz to understand the complex functions of ApoD in mammalian aging and neurodegeneration.es_ES
dc.description.sponsorshipThis work was supported by start-up grants to D.S. and M.D.G. from the “Ramón y Cajal Program” (Ministerio de Ciencia y Tecnología—Spain, and Fondo Europeo de Desarrollo Regional SGFRH Foundation; Junta de Castilla y Leon grant VA049A0, Ministerio de Educacion y Ciencia grant BFU2005-00522, and Ministerio de Ciencia e Innovacion grant BFU2008-01170 to M.D.G. and D.S.; Ministerio de Ciencia e Innovacion grant BFU2008-04683-C02-02 to I.C.; Ministerio de Ciencia e Innovacion grant BFU2009-12410/BMC and Fundación Cien Reina Sofía to A.A.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.isversionofPostprint-
dc.rightsopenAccesses_ES
dc.subjectApoDes_ES
dc.subjectLazarilloes_ES
dc.subjectLifespanes_ES
dc.subjectAginges_ES
dc.subjectReproductiones_ES
dc.subjectStress-responsees_ES
dc.titleSex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLazes_ES
dc.typeArtículoes_ES
dc.identifier.doi10.1016/j.exger.2011.02.014-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.exger.2011.02.014es_ES
dc.contributor.funderMinisterio de Ciencia y Tecnología (España)-
dc.contributor.funderMinisterio de Educación y Ciencia (España)-
dc.contributor.funderEuropean Commission-
dc.contributor.funderSan Francisco General Hospital Foundation-
dc.contributor.funderInstituto de Salud Carlos III-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100006280es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100009490es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
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