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Altered expression of securin (Pttg1) and serpina3n in the auditory system of hearing-impaired Tff3-deficient mice

AuthorsLubka-Pathak, M.; Gallozi, Micaela; Schimmang, Thomas
KeywordsTrefoil peptides
Inferior colliculus
Expression patterns
Issue DateAug-2011
CitationCellular and Molecular Life Sciences 68(16): 2739-2749 (2011)
Abstract[Introduction]: Tff3 peptide exerts important functions in cytoprotection and restitution of the gastrointestinal (GI) tract epithelia. Moreover, its presence in the rodent inner ear and involvement in the hearing process was demonstrated recently. However, its role in the auditory system still remains elusive. Our previous results showed a deterioration of hearing with age in Tff3-deficient animals. [Results]: Present detailed analysis of auditory brain stem response (ABR) measurements and immunohistochemical study of selected functional proteins indicated a normal function and phenotype of the cochlea in Tff3 mutants. However, a microarray-based screening of tissue derived from the auditory central nervous system revealed an alteration of securin (Pttg1) and serpina3n expression between wild-type and Tff3 knock-out animals. This was confirmed by qRT-PCR, immunostaining and western blots.
Description11 páginas, 5 figuras, 1 tabla.-- et al.-- El pdf del artículo es la versión post-print.
Publisher version (URL)http://dx.doi.org/10.1007/s00018-010-0586-1
Appears in Collections:(IBGM) Artículos
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